Break-induced replication is activated to repair R-loop-associated double-strand breaks in SETX-deficient cells
Tong Wu, Youhang Li, Yuqin Zhao…·Xiaohua Wu
This study shows that BIR is activated to repair R-loop-associated double-strand breaks in SETX-deficient cells, leading to hyper-recombination and synthetic lethality with PIF1, RAD52, and XPF.