PhysiologybioRxivPreprint
Histone lysine demethylase inhibition is a disease-modifying therapy for hypertrophic cardiomyopathy
Manjeet Singh, Yan Fan, Damir Alzhanov…·Zhi‐Ping Liu
This study shows that inhibiting histone lysine demethylases with JIB-04 prevents and reverses hypertrophic cardiomyopathy through epigenetic changes.