Cancer BiologybioRxivPreprint
Loss of NKX2-1 predisposes thyroid to neoplasm development through regulation of oxidative stress
Yo-Taro Shirai, Jerrold Michael Ward, Yoshinori Takizawa…·Shioko Kimura
The paper shows that loss of NKX2-1 increases thyroid cancer risk by promoting oxidative stress through ROS production and DNA damage in mice exposed to radiation and iodine deficiency.
DOI 10.64898/2026.08.26.746581