Author

U. Hellmich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Wiedemann· 2 shared B. Kokona· 1 shared C. Sotriffer· 1 shared G. Hamrick· 1 shared H. Schindelin· 1 shared J. Beld· 1 shared J. Kehrein· 1 shared K. K. Li· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

C. Wiedemann

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2 papers

Recent·Most cited

Strategic acyl carrier protein engineering enables functional type II polyketide synthase reconstitution in vitro

K. K. Li, Y. I. Cho, M. A. Tran, C. Wiedemann, S. Zhang, R. S. Koweek, N. K. Hoang, G. Hamrick, M. Bowen, B. Kokona, P. Stallforth, J. Beld, U. Hellmich, L. K. Charkoudian

This study enables functional reconstitution of type II PKS in vitro by engineering acyl carrier proteins to be activatable by Sfp.

bioRxiv · Aug 2, 2023Biochemistry

Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97

S. Bothe, P. Haenzelmann, S. Boehler, J. Kehrein, C. Wiedemann, U. Hellmich, R. Brenk, H. Schindelin, C. Sotriffer

The paper uses biolayer interferometry to identify small molecule ligands targeting the SHP-motif binding site of p97, leading to the first structure of a small molecule complex with the N-domain of p97.

bioRxiv · Jun 1, 2022Biochemistry