Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetes patients
J. Farup, J. Just, F. de Paoli, L. Lin, J. B. Jensen, T. Billeskov, I. S. Roman, C. Comert, A. B. Moeller, L. Madaro, E. Groppa, R. G. Fred, U. Kampmann, S. B. Pedersen, P. Bross, , N. Jessen
This study identifies CD90+ fibro-adipogenic progenitors in T2DM skeletal muscle and shows PDGF signaling drives their pathogenic behavior, which is mitigated by Metformin.
bioRxiv · Aug 25, 2020Cell Biology