F. M. V. Rossi

This study shows mesenchymal progenitors regulate the balance between type 1 and type 2 inflammation via the TAK1-NFkB pathway, with implications for inflammatory diseases.

The paper screens drugs to block fibrogenic differentiation in Duchenne Muscular Dystrophy mice, but finds no significant improvement in muscle histopathology despite in vitro hits.

This study identifies CD90+ fibro-adipogenic progenitors in T2DM skeletal muscle and shows PDGF signaling drives their pathogenic behavior, which is mitigated by Metformin.

The paper shows TGF-β reduces TCF7L2 expression in PDGFR+ fibroblasts via the ubiquitin-proteasome system and HDACs, impacting Wnt signaling in tissue repair.