Ergosterol mediates aggregation of natamycin in the yeast plasma membrane
M. Szomek, V. Akkerman, L. Lauritsen, H.-L. Walther, A. D. Juhl, K. Thaysen, J. M. Egebjerg, D. F. Covey, M. Lehmann, P. Wessig, A. J. Foster, B. Poolman, S. Werner, G. Schneider, P. Müller, D. Wüstner
This paper shows that ergosterol mediates natamycin aggregation in yeast plasma membranes, which underlies its antifungal activity and can be enhanced by sphingolipid inhibitors.
bioRxiv · Dec 5, 2023 · PreprintBiophysics