S. Werner

Ergosterol mediates aggregation of natamycin in the yeast plasma membrane

This paper shows that ergosterol mediates natamycin aggregation in yeast plasma membranes, which underlies its antifungal activity and can be enhanced by sphingolipid inhibitors.

Kinetic modelling of sterol transport between plasma membrane and endo-lysosomes based on quantitative fluorescence and X-ray imaging data

The paper uses kinetic modeling of sterol transport data to show that NPC2 deficiency leads to lipid accumulation in LE/LYS intraluminal vesicles, supported by X-ray imaging.

IFT88 transports Gucy2d, a guanylyl cyclase, to maintain sensory cilia function in Drosophila

This study identifies IFT88 as a transporter of Gucy2d to sensory cilia in Drosophila, showing its role in maintaining ciliary function and sensory behavior.

A direct RNA-protein interaction atlas of the SARS-CoV-2 RNA in infected human cells

This study maps direct RNA-protein interactions of SARS-CoV-2 RNA in infected human cells using RAP-MS, identifying host factors, regulators, and potential drug targets involved in viral replication and host defense.

Analysis of cholesterol export from endo-lysosomes by Niemann Pick C2 protein using combined fluorescence and X-ray microscopy

This study uses fluorescence and X-ray microscopy to show NPC2 facilitates cholesterol export from endo-lysosomes, altering membrane trafficking and organelle structure.

Body size-dependent energy storage causes Kleiber’s law scaling of the metabolic rate in planarians

This study shows Kleiber’s law in planarians arises from size-dependent energy storage, not cellular metabolic rate changes.