Molecular Scale Spatio-Chemical Control of the Activating-Inhibitory Signal Integration in NK Cells
E. Toledo, G. Le Saux, L. Li, M. Rosengenrg, Y. Keidar, V. Bhingradive, A. Edri, U. Hadad, C. Di Primo, T. Buffeteau, A.-S. Smith, A. Porgador, M. Schvartzman
This study uses a nanoengineered cell niche to investigate how spatial positioning of activating and inhibitory ligands affects NK cell signaling, finding that a 40 nm gap optimally inhibits NKG2D signaling via KIR2DL1.
bioRxiv · Mar 24, 2020Immunology