ImmunologybioRxiv
Molecular Scale Spatio-Chemical Control of the Activating-Inhibitory Signal Integration in NK Cells
E. Toledo, G. Le Saux, L. Li…·M. Schvartzman
This study uses a nanoengineered cell niche to investigate how spatial positioning of activating and inhibitory ligands affects NK cell signaling, finding that a 40 nm gap optimally inhibits NKG2D signaling via KIR2DL1.
DOI 10.1126/sciadv.abc1640