Author

A.-S. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 3 Research Focus:development & morphogenesis· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:imaging· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

M. Hubert· 4 shared L. Li· 3 shared S. Gehrer· 3 shared C. Wollnik· 2 shared D. Dudziak· 2 shared D. Vurnek· 2 shared F. Rehfeldt· 2 shared F. Thibaudau· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersBiophysics

M. Hubert

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Laminin-defined Mechanical Status Modulates Retinal Pigment Epithelium Functionality

A. N. Kozyrina, T. Piskova, F. Semeraro, I. Doolaar, T. Prapty, T. Haraszti, M. Hubert, R. Windoffer, R. E. Leube, A.-S. Smith, J. Di Russo

This study shows that laminin density in the retinal pigment epithelium basement membrane modulates contractility and phagocytic efficiency, linking mechanical status to visual function.

bioRxiv · Feb 24, 2023Biophysics

Capturing the mechanosensitivity of cell proliferation in models of epithelium

K. Hollring, L. Nuic, L. Rogic, S. Kaliman, S. Gehrer, C. Wollnik, F. Rehfeldt, M. Hubert, A.-S. Smith

The paper investigates how cell density and mechanical response influence cell proliferation in model tissues, showing that mechanoresponse and proliferation create an active pressure driving tissue growth.

bioRxiv · Jan 31, 2023Biophysics

Morphology as indicator of adaptive changes of model tissues in osmotically and chemically changing environments

K. Höllring, D. Vurnek, S. Gehrer, D. Dudziak, M. Hubert, A.-S. Smith

The paper investigates how hyperosmotic environments affect 2D epithelial tissue morphology, topology, and homeostasis over time.

bioRxiv · Jan 18, 2023Biophysics

On the mechanical regulation of epithelial tissue homeostasis

S. Kaliman, M. Hubert, C. Wollnik, L. Nuic, D. Vurnek, S. Gehrer, J. Lovric, D. Dudziak, F. Rehfeldt, A.-S. Smith

This study shows matrix stiffness changes induce a non-equilibrium transition in epithelial tissues and reveals a complex relationship between cell density and motility.

bioRxiv · Apr 10, 2021Biophysics

Principles of organelle membranebridging established using cytosolictether mimics

M. A. Kamal, J. A. Janes, L. Li, F. Thibaudau, A.-S. Smith, K. Sengupta

The paper establishes principles of organelle membrane bridging using DNA tether mimics in GUV and SLB systems, showing adhesion driven by entropic effects rather than enthalpic binding.

bioRxiv · Sep 2, 2020 · PreprintBiophysics

Coexistence of long and short DNA constructs within adhesion plaques

L. Li, M. A. Kamal, H. Stumpf, F. Thibaudau, K. Sengupta, A.-S. Smith

The paper studies DNA bridge organization in adhesion domains using a model system, finding coexisting long and short DNA constructs despite length differences.

bioRxiv · May 12, 2020 · PreprintBiophysics

Molecular Scale Spatio-Chemical Control of the Activating-Inhibitory Signal Integration in NK Cells

E. Toledo, G. Le Saux, L. Li, M. Rosengenrg, Y. Keidar, V. Bhingradive, A. Edri, U. Hadad, C. Di Primo, T. Buffeteau, A.-S. Smith, A. Porgador, M. Schvartzman

This study uses a nanoengineered cell niche to investigate how spatial positioning of activating and inhibitory ligands affects NK cell signaling, finding that a 40 nm gap optimally inhibits NKG2D signaling via KIR2DL1.

bioRxiv · Mar 24, 2020Immunology