V. Bucci

Microbiota encoded fatty-acid metabolism expands tuft cells to protect tissues homeostasis during Clostridioides difficile infection in the large intestine

This study shows that succinate from the microbiota expands tuft cells in the colon, enhancing type 2 immunity and reducing C. difficile-induced disease.

Expanding the toolbox: Novel class IIb microcins show activity against gram-negative ESKAPE and plant pathogens

The paper identifies twelve new class IIb microcins from seven Enterobacteriaceae species and validates their activity against Gram-negative pathogens and plant pathogens.

Microcin MccI47 selectively inhibits enteric bacteria and reduces carbapenem-resistant Klebsiella pneumoniae colonization in vivo when administered via an engineered live biotherapeutic

This paper demonstrates that engineered live biotherapeutic Escherichia coli producing microcin MccI47 reduces carbapenem-resistant Klebsiella pneumoniae colonization in mice without disrupting the microbiota.

Proanthocyanidin-enriched cranberry extract induces resilient bacterial community dynamics in a gnotobiotic mouse model

This study shows that a proanthocyanidin-enriched cranberry extract alters bacterial community dynamics in a gnotobiotic mouse model, with transient increases in mucin-degrading and anti-inflammatory bacteria.

Biofilm structure promotes coexistence of phage-resistant and phage-susceptible bacteria

The paper uses simulations and experiments to show that biofilm structure promotes coexistence of phage-resistant and phage-susceptible bacteria compared to planktonic cultures.

Phage mobility is a core determinant of phage-bacteria coexistence in biofilms

This study develops a biofilm simulation framework to explore how phage mobility affects coexistence with bacteria in biofilms, finding that phage diffusion through the biofilm matrix is a key determinant of their interaction dynamics.