Microbiota encoded fatty-acid metabolism expands tuft cells to protect tissues homeostasis during Clostridioides difficile infection in the large intestine
T. D. Kellogg, S. Ceglia, B. M. Mortzfeld, A. L. Zeamer, S. E. Foley, D. Ward, S. K. Bhattarai, B. A. McCormick, A. Reboldi, V. Bucci
This study shows that succinate from the microbiota expands tuft cells in the colon, enhancing type 2 immunity and reducing C. difficile-induced disease.
bioRxiv · Jan 29, 2024 · PreprintImmunology