Host-microbe interactions mediate doramectin-promoted metabolic reprogramming of CD8+ T-cells and amplify antitumor immunity
S. Taghinezhad-S, A. H. Mohseni, W. Jiang, V. Casolaro, L. G. Bermudez-Humaran, F. McAllister, Z. Lv, D. Li
This study shows that doramectin promotes CD8+ T-cell metabolic reprogramming and antitumor immunity, mediated by gut microbiota interactions.
bioRxiv · Jan 29, 2023 · PreprintCancer Biology