W. Jiang

Marker-specific pixel attribution for single-cell protein quantification with PixAQ

PixAQ improves single-cell protein quantification in imaging mass cytometry by assigning pixel signals to specific markers using spatial and intensity models.

A Host Enzyme Reduces Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Inactivating Intestinal Lipopolysaccharide

This study shows that AOAH inactivates intestinal LPS, reducing MASLD by preventing hepatic lipid accumulation and altering lipid metabolism gene expression.

The effects of L-carnitine and fructose in improved Ham's F10 on sperm culture in idiopathic severe asthenospermia within 24h

This study evaluates the effects of L-carnitine and fructose in modified Ham's F10 medium on sperm motility in idiopathic severe asthenospermia patients within 24h, finding improved viability at specific concentrations and temperature.

CD388: A universally protective Drug-Fc Conjugate that targets influenza virus neuraminidase

This paper describes CD388, a drug-Fc conjugate that targets influenza virus neuraminidase, showing universal antiviral activity across multiple strains and demonstrating efficacy in mouse models.

Active E. coli heteromeric acetyl-CoA carboxylase forms polymorphic helical tubular filaments

The paper reports that E. coli heteromeric acetyl-CoA carboxylase forms polymorphic helical tubular filaments, revealing protein-protein interactions that support catalysis and mask transcriptional regulation.

Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform

This study identifies new PPM1D inhibitors using a drug discovery platform and shows their distinct biological effects compared to other DDR and p53 pathway modulators.

Efficient Gene Editing and Overexpression of Gametophyte Transformation in a Model Fern

This paper develops a CRISPR/Cas9 system for efficient gene editing and overexpression in the fern Ceratopteris richardii, demonstrating functional effects on stomatal and photosynthetic traits.

Inhibitory KIRs decrease HLA class II-mediated protection in Type 1 Diabetes

The paper investigates how inhibitory KIRs modify HLA class II protective associations in Type 1 Diabetes, finding that iKIRs reduce HLA class II-mediated protection.

Illuminating the Dark Cancer Phosphoproteome Through a Machine-Learned Co-Regulation Map of 26,280 Phosphosites

The paper constructs a co-regulation map of phosphosites using machine learning and phosphoproteomic data, revealing kinase-substrate associations and identifying potential therapeutic targets in cancer.

Gut Eggerthella lenta promotes the efficacy of resveratrol through reductive metabolism

This study identifies Eggerthella lenta as a key gut bacterium that enhances resveratrol's efficacy through reductive metabolism, producing a more active metabolite.

Suppressing APOE4-induced mortality and cellular damage by targeting VHL

This study shows that targeting the VHL-HIF axis suppresses mortality and cellular damage caused by APOE4 and other stressors in C. elegans and mice.

Large-pore connexin hemichannels function as molecule transporters independently of ion conduction

The paper shows that connexin hemichannels can transport molecules independently of ion conduction, challenging the conventional view of their function.

Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing

This study uses scRNA-seq to analyze how chemotherapy remodels the immune landscape and metabolic state in lung adenocarcinoma, identifying changes in macrophage subtypes and immune responses.

A Vascular Dissection and Rupture Linked Metabolite Acts Via BLT2 Receptor

This study identifies 12-HETE as a key metabolite in thoracic aortic dissection (TAD) that activates BLT2 receptors on macrophages, driving inflammation and VSMC phenotype switching, and shows that targeting this pathway can reduce TAD progression.

Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer

The paper shows that ZNRF3/RNF43 ubiquitinates and degrades EGFR, and their loss increases EGFR signaling, promoting cancer growth.

A Murine Model of Post-acute Neurological Sequelae Following SARS-CoV-2 Variant Infection

This study uses a murine model to investigate persistent neurological symptoms after SARS-CoV-2 Delta variant infection, finding long-term immune activation and behavioral abnormalities.

A Mouse Model of the Protease Activated Receptor 4 (PAR4) Pro310Leu Variant has Reduced Platelet Reactivity

This study creates a mouse model of the PAR4-P310L variant and shows reduced platelet reactivity to PAR4-activation peptide and thrombin, with no effect on ADP and convulxin responses.

metaExpertPro: a computational workflow for metaproteomics spectral library construction and data-independent acquisition mass spectrometry data analysis

metaExpertPro constructs metaproteomics spectral libraries and analyzes DIA-MS data, achieving high peptide quantification and low FDR in human fecal samples.

Filter-aided expansion proteomics

The paper introduces FAXP, a method combining hydrogel expansion and mass spectrometry for high-resolution proteomics of FFPE tissues, showing improved resolution and efficiency over existing methods.

Ultra-Long-Term Delivery of Hydrophilic Drugs Using Injectable In Situ Cross-Linked Depots

This paper develops an injectable platform for ultra-long-term hydrophilic drug delivery, achieving sustained release over six months in vivo.

A neuronal circuit driven by GLP-1 in the olfactory bulb regulates insulin secretion

This study shows that GLP-1 receptor activation in the olfactory bulb enhances insulin secretion via a sympathetic pathway involving the paraventricular nucleus.

Classification of helical polymers with deep-learning language models

This paper introduces HLM, a deep-learning language model-based method for classifying helical polymers from cryo-EM images, showing it can distinguish filament types and identify new densities in tau filaments.

PSTPIP2 ameliorates aristolochic acid nephropathy by suppressing interleukin-19-mediated neutrophil extracellular trap formation

This study shows PSTPIP2 reduces kidney damage in AAN by suppressing IL-19-mediated NET formation and inflammation.

Molecular Evolution and Interaction of 14-3-3 Proteins with H+-ATPases in Plant Abiotic Stresses

This paper reviews the roles of 14-3-3 proteins and H+-ATPases in plant abiotic stress responses and analyzes their molecular evolution across species.

A DNA Unwinding Equilibrium Serves as a Checkpoint for CRISPR-Cas12a Target Discrimination

This study investigates Cas12a's target discrimination mechanism, revealing a DNA unwinding equilibrium as a checkpoint for mismatch sensing before cleavage.

Fortuitous Somatic Mutations during Antibody Evolution Endow Broad Neutralization against SARS-CoV-2 Omicron Variants

The paper identifies an antibody with broad neutralization against SARS-CoV-2 Omicron variants and shows how somatic mutations enhance its neutralization breadth and potency.

Carcinoma-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment

This study identifies a subpopulation of Ewing sarcoma cells with CAF-like properties that remodel the tumor microenvironment through ECM deposition.

Mammalian Esophageal Stratified Tissue Homeostasis is Maintained Distinctively by the Epithelial Pluripotent p63+Sox2+ and p63-Sox2+ Cell Populations

This study identifies two distinct cell populations, p63+Sox2+ and p63-Sox2+, that maintain esophageal tissue homeostasis through different roles in stemness, differentiation, and damage repair.

An ULK1/2-PXN mechanotransduction complex suppresses breast cancer cell migration

This study identifies ULK1/2 as regulators of PXN-dependent mechanotransduction in breast cancer cells, showing their role in inhibiting migration by modulating focal adhesion assembly.

Host-microbe interactions mediate doramectin-promoted metabolic reprogramming of CD8+ T-cells and amplify antitumor immunity

This study shows that doramectin promotes CD8+ T-cell metabolic reprogramming and antitumor immunity, mediated by gut microbiota interactions.