Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2
O. Tsyklauri, T. Chadimova, V. Niederlova, J. Kovarova, J. Michalik, I. Malatova, S. Janusova, O. Ivashchenko, H. Rossez, A. Drobek, H. Vecerova, V. Galati, M. Kovar, O. Stepanek
This study identifies Tregs suppressing KLRK1+ IL7R+ CD8+ effector T cells by limiting IL-2, which enhances autoimmunity and anti-tumor responses.
bioRxiv · Nov 10, 2021Immunology