A Patient-Derived Cellular Model for Huntington Disease Reveals Phenotypes at Clinically Relevant CAG Lengths
C. L. K. Hung, T. Maiuri, L. E. Bowie, R. Gotesman, S. Son, M. Falcone, J. V. Giordano, V. Mattis, T. Lau, V. Kwan, V. Wheeler, J. Schertzer, K. Singh, R. Truant
This paper develops a patient-derived cellular model for Huntington Disease that maintains TP53 function and exhibits HD phenotypes at clinically relevant CAG lengths.
bioRxiv · Apr 12, 2018Cell Biology