Author

S. Son

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Biophysics· 3 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Research Focus:cell signaling & trafficking· 6 Research Focus:cell type annotation· 5 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

D. A. Fletcher· 7 shared B. Belardi· 2 shared D. Lee· 2 shared K. M. C. Chan· 2 shared M. H. Bakalar· 2 shared M. Podolski· 2 shared P. J. Butler· 2 shared A. Bhat· 1 shared

Activity by Year

2017-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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7 shared papersCell Biology

D. A. Fletcher

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Engineered molecular sensors of cell surface crowding

S. C. Takatori, S. Son, D. Lee, D. A. Fletcher

This paper designs molecular sensors to quantify cell surface crowding and shows it affects ligand binding and varies with cell type and oncogene expression.

bioRxiv · Nov 18, 2022 · PreprintBiophysics

Evolutionarily related small viral fusogens hijack distinct but modular actin nucleation pathways to drive cell-cell fusion

K. M. C. Chan, A. L. Arthur, J. Morstein, M. Jin, A. Bhat, D. Schlesinger, S. Son, D. A. Stevens, D. G. Drubin, D. A. Fletcher

This study shows that two FAST proteins use distinct actin nucleation pathways to drive cell-cell fusion, but their cytoplasmic tails are modular and functionally interchangeable.

bioRxiv · Jun 3, 2020Cell Biology

Molecular height measurement by cell surface optical profilometry (CSOP)

S. Son, S. Takatori, B. Belardi, M. Podolski, M. H. Bakalar, D. A. Fletcher

The paper introduces CSOP, a method to measure molecular heights on cell surfaces with nanometer resolution, and finds that protein height is smaller than contour length and depends on surface and solution conditions.

bioRxiv · Dec 31, 2019Biophysics

A viral fusogen hijacks the actin cytoskeleton to drive cell-cell fusion

K. M. C. Chan, S. Son, E. M. Schmid, D. A. Fletcher

This study shows a viral fusogen uses the actin cytoskeleton to drive cell-cell fusion without requiring conformational changes of its short ectodomain.

bioRxiv · Sep 8, 2019Cell Biology

In situ, fluorescence lifetime-based measurements of cell membrane micromechanics

S. Son, H. S. Muddana, C. Huang, S. Zhang, P. J. Butler

This paper develops a method to measure cell membrane micromechanics using fluorescence lifetime imaging of DiI, enabling analysis of lipid bilayer properties in situ.

bioRxiv · Jul 16, 2019 · PreprintBiophysics

Motility of Enzyme-Powered Vesicles

S. Ghosh, F. Mohajerani, S. Son, D. Velegol, P. J. Butler, A. Sen

The paper demonstrates that enzyme-powered vesicles exhibit increased motility with higher enzymatic turnover rates, using optical microscopy to track their movement.

bioRxiv · May 22, 2019Biochemistry

Moments reconstruction and local dynamic range compression of high order Superresolution optical fluctuation imaging

X. Yi, S. Son, R. Ando, A. Miyawaki, S. Weiss

This paper compares high order moments and cumulants SOFI reconstructions, showing that moments are free of cusp artifacts and enable improved resolution through deconvolution.

bioRxiv · Mar 28, 2019Bioengineering

Claudin-4 Reconstituted in Unilamellar Vesicles is Sufficient to Form Tight Interfaces that Partition Membrane Proteins

B. Belardi, S. Son, M. D. Vahey, J. Wang, J. Hou, D. A. Fletcher

This study shows that claudin-4 reconstituted in vesicles forms tight interfaces that partition membrane proteins, supporting its role as a molecular fence in epithelial polarization.

bioRxiv · Apr 27, 2018Cell Biology

A Patient-Derived Cellular Model for Huntington Disease Reveals Phenotypes at Clinically Relevant CAG Lengths

C. L. K. Hung, T. Maiuri, L. E. Bowie, R. Gotesman, S. Son, M. Falcone, J. V. Giordano, V. Mattis, T. Lau, V. Kwan, V. Wheeler, J. Schertzer, K. Singh, R. Truant

This paper develops a patient-derived cellular model for Huntington Disease that maintains TP53 function and exhibits HD phenotypes at clinically relevant CAG lengths.

bioRxiv · Apr 12, 2018Cell Biology

Size-dependent segregation controls macrophage phagocytosis of antibody-opsonized targets

M. H. Bakalar, A. M. Joffe, E. Schmid, S. Son, M. Podolski, D. A. Fletcher

This study identifies an antigen height threshold that regulates macrophage phagocytosis of antibody-opsonized targets, showing that antigens taller than 10 nm impair phagocytosis by disrupting Fc receptor signaling.

bioRxiv · Jan 19, 2018Cell Biology

Spectrin is a mechanoresponsive protein shaping the architecture of intercellular invasion

R. Duan, J. H. Kim, K. Shilagardi, E. Schiffhauer, S. Son, D. Lee, S. Li, C. Thomas, T. Luo, D. A. Fletcher, D. N. Robinson, E. H. Chen

The paper shows spectrin dynamically accumulates at fusogenic synapses in response to shear deformation, forming a sieve-like network that promotes cell membrane fusion during intercellular invasion.

bioRxiv · Jun 23, 2017Cell Biology