Author

T. Lau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

A. Cabrera-Cortez· 1 shared A. Karsan· 1 shared A. Lentz· 1 shared A. Y.-C. Mo· 1 shared B. D. Henriksbo· 1 shared B. M. Duggan· 1 shared C. L. K. Hung· 1 shared C. Y. Chen· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperMicrobiology

A. Cabrera-Cortez

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Loss of FBXO11 function establishes a stem cell program in acute myeloid leukemia through dysregulation of the mitochondrial LONP1

A. Y.-C. Mo, H. Kincross, X. Wang, L. Y.-T. Chang, G. Duns, F. Mey, Z. Zhu, H. Kwan, T. Lau, T. R. Docking, J. Tran, S. Colborne, S.-W. G. Cheng, S. Huang, N. Gharaee, , A. Karsan

This study identifies FBXO11 loss as a driver of AML by promoting a stem cell program through mitochondrial dysregulation.

bioRxiv · Sep 10, 2022 · PreprintCancer Biology

Developing Cyclic Peptomers as Broad-Spectrum Gram negative Bacterial Type III Secretion System Inhibitors

H. Lam, T. Lau, A. Lentz, J. Sherry, A. Cabrera-Cortez, K. Hug, J. Engel, S. Lokey, V. Auerbach Stone

This paper identifies a cyclic peptomer, 4EpDN, that broadly inhibits Gram-negative bacterial type III secretion systems without affecting bacterial growth or other secretory systems.

bioRxiv · Aug 3, 2020Microbiology

Gut microbiota impairs insulin clearance during obesity

K. P. Foley, S. Zlitni, B. M. Duggan, N. Barra, F. F. Anhe, J. F. Cavallari, B. D. Henriksbo, C. Y. Chen, M. Huang, T. Lau, J. D. Schertzer

This study shows that gut microbiota impair insulin clearance during obesity, with specific bacterial taxa linked to this effect, suggesting potential therapeutic targets.

bioRxiv · May 8, 2020 · PreprintPhysiology

A Patient-Derived Cellular Model for Huntington Disease Reveals Phenotypes at Clinically Relevant CAG Lengths

C. L. K. Hung, T. Maiuri, L. E. Bowie, R. Gotesman, S. Son, M. Falcone, J. V. Giordano, V. Mattis, T. Lau, V. Kwan, V. Wheeler, J. Schertzer, K. Singh, R. Truant

This paper develops a patient-derived cellular model for Huntington Disease that maintains TP53 function and exhibits HD phenotypes at clinically relevant CAG lengths.

bioRxiv · Apr 12, 2018Cell Biology