Peyers Patch B cells undergo cell death via neutrophil-released toxic DNA following sterile tissue injury
A. A. Tuz, A. Beer, M. Gallert, D. Ttoouli, S. Ghosh, S. P. Sata, A. Kraus, F. Zwirnlein, V. Kaygusuz, V. Lakovic, A. Qefalia, M. Antler, S. Korste, B. Kaltwasser, H. Abdelrahman, , V. Singh
The paper shows that sterile tissue injury causes B cell death in Peyers patches via neutrophil-released toxic DNA, leading to tissue shrinkage and reduced secretory IgA.
bioRxiv · Nov 9, 2022Immunology