Cancer BiologybioRxiv
Co-occurring alterations in the RAS-MAPK pathway limit response to MET inhibitor treatment in MET exon 14 skipping mutation positive lung cancer
J. K. Rotow, P. Gui, W. Wu…·C. M. Blakely
The paper identifies co-occurring RAS-MAPK pathway alterations in MET exon 14 skipping mutation positive lung cancers that limit response to MET inhibitors and suggests combining MET and MEK inhibitors to overcome resistance.
DOI 10.1158/1078-0432.ccr-19-1667