V. Manda

Improved determination of protein turnover rate with heavy water labeling by mass isotopomer ratio selection

This paper introduces a method to improve protein turnover rate calculation using heavy water labeling and mass spectrometry, increasing coverage of well-fitted peptides by 25-82% in mouse organ proteomes.

Simultaneous proteome localization and turnover analysis reveals spatiotemporal dynamics of unfolded protein responses

This study introduces SPLAT, a proteomics method to analyze protein turnover and localization simultaneously, revealing spatiotemporal changes in the unfolded protein response in human cells.