C. Lai

Chemoresistance of TP53 mutant AML requires the mevalonate byproduct, GGPP, for regulation of ROS and induction of a mitochondria stress response

This study identifies GGPP, a mevalonate pathway byproduct, as critical for chemoresistance in TP53mut AML through ROS regulation and mitochondria stress response, suggesting statin-based therapies could be effective.

Nitrate-driven anaerobic oxidation of ethane and butane by bacteria

This study demonstrates nitrate-dependent anaerobic oxidation of ethane and butane by Candidatus Alkanivorans nitratireducens, revealing the fumarate addition pathway's role in SCGA metabolism.

Establishment of hairy root culture and its genetic transformation of Stephania tetrandra S. Moore for production of BIAs

This paper establishes a hairy root culture and genetic transformation system in Stephania tetrandra to enhance bisbenzylisoquinoline alkaloid production.

Simultaneous proteome localization and turnover analysis reveals spatiotemporal dynamics of unfolded protein responses

This study introduces SPLAT, a proteomics method to analyze protein turnover and localization simultaneously, revealing spatiotemporal changes in the unfolded protein response in human cells.

Programmed cell death-1 receptor mediated regulation of Tbet+ NK1.1- Innate Lymphoid Cells within the Tumor Microenvironment

This paper identifies Tbet+NK1.1- ILCs in the tumor microenvironment and shows PD-1 regulates their proliferation and anti-tumor function through metabolic changes.

Generating Functional Cells Through Enhanced Interspecies Chimerism with Human Pluripotent Stem Cells

This study demonstrates that MYCN and BCL2 enhance interspecies chimerism with human pluripotent stem cells, enabling the generation of functional human blood progenitor cells in chimeric embryos.

Tuning the sensitivity of genetically encoded fluorescent potassium indicators through structure-guided and genome mining strategies

The paper develops genetically encoded fluorescent potassium indicators with tunable binding affinities through structure-guided design and genome mining, showing varying Kd values in vitro and in cells.

VGLL1 drives therapy resistance in estrogen receptor positive breast cancer

This study identifies VGLL1 as a driver of resistance to endocrine therapy in ER+ breast cancer and shows that targeting VGLL1/TEAD interaction can inhibit resistant cell growth.

TP53 abnormalities correlate with immune infiltration and are associated with response to flotetuzumab, an investigational immunotherapy, in acute myeloid leukemia

This paper shows TP53 mutations in AML are linked to immune features and improved response to flotetuzumab immunotherapy.

Long noncoding RNA AVAN promotes antiviral innate immunity by interacting with TRIM25 and enhancing the transcription of FOXO3a

This study identifies lncRNA AVAN as a positive regulator of antiviral innate immunity by interacting with TRIM25 and enhancing FOXO3a transcription.

Response of soil microbial communities to alpine meadow degradation severity levels in the Qinghai-Tibet Plateau

This study examines how soil microbial communities change with alpine meadow degradation severity on the Qinghai-Tibet Plateau, finding shifts in bacterial and fungal phyla and associations with soil and plant properties.

Molecular measurable residual disease testing of blood during AML cytotoxic therapy for early prediction of clinical response

This study evaluates molecular residual disease in AML patients during chemotherapy, finding stable variant allele frequencies that may indicate limited therapeutic response.

Human Bone Marrow Assessment by Single Cell RNA Sequencing, Mass Cytometry and Flow Cytometry

The paper assesses human bone marrow cells using single-cell RNA sequencing, flow cytometry, and mass cytometry to evaluate technical and biological variation across age groups.