Author

E. Lau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Biochemistry· 3 Cell Biology· 1 Immunology· 1 Microbiology· 1

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Assay:proteomics· 7 Organism:mouse· 6 Research Focus:cell type annotation· 5 Research Focus:differential expression· 5 Approach:experimental assay· 5 Organism:human· 5 Approach:statistical model· 4 Assay:bulk RNA-seq· 2

Frequent Co-Authors

M. P. Y. Lam· 7 shared Y. Han· 4 shared B. Pandi· 3 shared D. C. M. Ng· 3 shared R. W. Ludwig· 3 shared A. Black· 2 shared C. T. Thomas· 2 shared J. Currie· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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7 shared papersBiochemistry

M. P. Y. Lam

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10 papers

Recent·Most cited

Improved determination of protein turnover rate with heavy water labeling by mass isotopomer ratio selection

J. Currie, D. C. M. Ng, B. Pandi, A. Black, V. Manda, J. Pavelka, M. P. Y. Lam, E. Lau

This paper introduces a method to improve protein turnover rate calculation using heavy water labeling and mass spectrometry, increasing coverage of well-fitted peptides by 25-82% in mouse organ proteomes.

bioRxiv · Jun 4, 2024 · PreprintBiochemistry

A Ratiometric Catalog of Protein Isoform Shifts in the Cardiac Fetal Gene Program

Y. Han, S. Binti, S. A. Wennersten, B. Pandi, D. C. M. Ng, E. Lau, M. P. Y. Lam

The paper identifies widespread isoform usage shifts in fetal and postnatal mouse hearts using proteome-wide ratio quantification, revealing novel isoform switches and evolutionary patterns.

bioRxiv · Apr 9, 2024Biochemistry

Tissue Usage Preference and Intrinsically Disordered Region Remodeling of Alternative Splicing Derived Proteoforms in the Heart

B. Pandi, S. Brenman, A. Black, D. C. M. Ng, E. Lau, M. P. Y. Lam

The paper analyzes mass spectrometry data to identify alternative splicing-derived protein variants in human heart chambers, finding tissue-specific isoforms and their functional implications in protein binding.

bioRxiv · Oct 8, 2023 · PreprintBiochemistry

Imprinted anti-hemagglutinin and anti-neuraminidase antibody responses after childhood infections of A(H1N1) and A(H1N1)pdm09 influenza viruses

P. Daulagala, B. Mann, K. Leung, E. Lau, L. Yung, R. Lei, S. I. N. Nizami, J. T. Wu, S. S. Chiu, R. S. Daniels, N. C. Wu, D. E. Wentworth, J. S. M. Peiris, H.-L. Yen

The paper characterizes anti-HA and anti-NA antibody responses to A(H1N1) and A(H1N1)pdm09 influenza viruses in individuals born between 1950-2015, finding age-dependent imprinting and cross-reactivity to multiple antigenic variants.

bioRxiv · Feb 1, 2023Microbiology

Simultaneous proteome localization and turnover analysis reveals spatiotemporal dynamics of unfolded protein responses

J. Currie, V. Manda, S. K. Robinson, C. Lai, V. Agnihotri, V. Hidalgo, R. W. Ludwig, K. Zhang, Z. V. Wang, J.-W. Rhee, M. P. Y. Lam, E. Lau

This study introduces SPLAT, a proteomics method to analyze protein turnover and localization simultaneously, revealing spatiotemporal changes in the unfolded protein response in human cells.

bioRxiv · Jan 4, 2023Cell Biology

Proteogenomic characterization of age and sex interactions in cardiac gene expression

Y. Han, S. A. Wennersten, J. Wright, R. W. Ludwig, E. Lau, M. P. Y. Lam

This study uses proteogenomics to identify age and sex-dependent gene expression and splicing changes in mouse hearts, revealing sexual dimorphism in cardiac aging and regulatory networks.

bioRxiv · May 11, 2022Physiology

Harmonizing labeling and analytical strategies to obtain protein turnover rates in intact adult animals.

D. E. Hammond, D. M. Simpson, C. Franco, M. W. Muelas, J. Waters, R. W. Ludwig, M. C. Prescott, J. L. Hurst, R. J. Beynon, E. Lau

This study compares protein turnover rates in mouse tissues using two labeling methods, showing they yield similar results for long-lived proteins but require adjustments for short-lived proteins.

bioRxiv · Dec 13, 2021Physiology

Transcriptome features of striated muscle aging and predictability of protein level changes

Y. Han, L. Z. Li, N. L. Kastury, C. T. Thomas, M. P. Y. Lam, E. Lau

The paper identifies transcriptomic signatures in aging striated muscle that predict protein level changes and prioritizes genes with age-dependent expression in humans.

bioRxiv · Jun 12, 2021Physiology

Proteomic signatures of acute oxidative stress response to paraquat in the mouse heart

V. Dostal, S. D. Wood, C. T. Thomas, Y. Han, E. Lau, M. P. Y. Lam

This study identifies proteomic changes in mouse hearts after paraquat exposure, showing mitochondrial dysfunction and antioxidant activation, with limited overlap with lung responses.

bioRxiv · May 29, 2020Physiology

Context-specific regulation of monocyte surface IL7R expression and soluble receptor secretion by a common autoimmune risk allele

H. Al-Mossawi, N. Yager, C. Taylor, E. Lau, S. Danielli, J. de Wit, S. Makino, J. Gilchrist, W. Lee, I. Nassiri, E. A. Mahe, L. Rizvi, J. Cheeseman, M. Neville, J. C. Knight, , B. P. Fairfax

The paper investigates how a genetic variant affects IL7R expression and soluble receptor secretion in monocytes under inflammatory conditions.

bioRxiv · Jul 15, 2018 · PreprintImmunology