BiophysicsProceedings of the National Academy of SciencesPeer-reviewed
Imaging active site chemistry and protonation states: NMR crystallography of the tryptophan synthase α-aminoacrylate intermediate
J. B. Holmes, V. Liu, B. G. Caulkins…·L. J. Mueller
This paper uses NMR-assisted crystallography to determine the protonation states and structure of the tryptophan synthase α-aminoacrylate intermediate, revealing insights into its reactivity and catalytic mechanism.
DOI 10.1073/pnas.2109235119