A. Hassan

Sequential early-life viral infections modulate the microbiota and adaptive immune responses to systemic and mucosal vaccination

This study shows that sequential early-life viral infections in mice reduce antibody responses to SARS-CoV-2 vaccination while altering immune cell profiles and gut microbiota.

Low intensity mechanical signals promote proliferation in a cell-specific manner: Tailoring a non-drug strategy to enhance biomanufacturing yields.

The paper tests low-intensity vibration to enhance cell proliferation in biomanufacturing, showing it can be tailored to different cell types to improve yields.

Beyond venomous fangs: Uloboridae spiders have lost their venom but not their toxicity

This study investigates Uloboridae spiders' venom loss and toxicity, finding they lack venom glands but retain toxin-like genes in digestive fluids with different toxic mechanisms.

Structure of mitoribosome reveals mechanism of mRNA binding, tRNA interactions with L1 stalk, roles of cofactors and rRNA modifications

The paper presents a high-resolution structure of the human mitoribosome, revealing mechanisms of mRNA binding, tRNA interactions, and roles of cofactors and rRNA modifications.

Evolution of chemosensory tissues and cells across ecologically diverse Drosophilids

The paper analyzes chemosensory transcriptomes across six Drosophila species to understand how gene expression and cell types evolve, finding stabilizing selection and species-specific expression changes.

T cell subsets in chronic hepatitis C patients genotype 4 who achieved SVR following DAAs Therapy

The paper examines T cell subsets and their markers in genotype 4 HCV patients after DAA therapy, finding reduced exhausted T cells but incomplete immune restoration.

Imaging active site chemistry and protonation states: NMR crystallography of the tryptophan synthase α-aminoacrylate intermediate

This paper uses NMR-assisted crystallography to determine the protonation states and structure of the tryptophan synthase α-aminoacrylate intermediate, revealing insights into its reactivity and catalytic mechanism.

Increased Brain Volumetric Measurement Precision from Multi-Site 3D T1-weighted 3T Magnetic Resonance Imaging by Correcting Geometric Distortions

This study shows that correcting geometric distortions in multi-site MRI improves volumetric measurement precision in brain scans.

SMOG 2 and OpenSMOG: Extending the limits of structure-based models

This paper introduces SMOG 2 and OpenSMOG, extending structure-based models to handle large biomolecular systems with enhanced customization and integration with OpenMM.

Distinct states of proinsulin misfolding in MIDY

The paper investigates proinsulin misfolding in MIDY mutants, showing that disrupting the Cys(A6)-Cys(A11) bond can restore proper folding and ER export in some mutants.

A single intranasal or intramuscular immunization with chimpanzee adenovirus vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters.

This study compares intranasal and intramuscular delivery of a chimpanzee adenovirus-vectored SARS-CoV-2 vaccine in hamsters, finding that intranasal immunization provides superior protection against infection and inflammation.

Abnormal energy metabolism can alter foraging behavior in termites in different social contexts

This study shows that altering energy metabolism via IDH gene knockdown affects foraging behavior in termites, with social context modulating these effects.

The Vibrio cholerae cytotoxin MakA induces noncanonical autophagy resulting in the spatial inhibition of canonical autophagy

This study shows that Vibrio cholerae toxin MakA induces noncanonical autophagy, which inhibits canonical autophagy and immune responses like IL-1β secretion.

Intense expression of Neurokinin-1 Receptor is associated with Urothelial carcinoma

This study examines NK-1R expression in urothelial carcinoma and finds it is intensely expressed in high-grade cases, suggesting a potential diagnostic and therapeutic marker.

Elevated Neurokinin 1-Receptor Expression in uterine products of conception is associated with first trimester Miscarriages

This study examines NK-1R expression in products of conception and finds it is consistently high in miscarriage cases, suggesting its potential role in miscarriage pathophysiology.

Prognostic significance of Substance P/ Neurokinin 1 receptor and its association with hormonal receptors in breast carcinoma

The paper evaluates Substance P and NK-1R expression in breast carcinoma and finds significant association with tumor grade, suggesting potential as a biomarker and therapeutic target.

Segmentation-less, automated vascular vectorization robustly extracts neurovascular network statistics from in vivo two-photon images

This paper introduces a segmentation-less method for automated vascular vectorization from in vivo two-photon images, showing improved robustness to image quality compared to intensity-thresholded methods.

A virus hosted in malaria-infected blood protects against T cell-mediated inflammatory diseases by impairing DC function in a type I IFN-dependent manner

This study identifies an RNA virus co-hosted in malaria parasites that protects against T cell-mediated inflammatory diseases by impairing dendritic cell function through type I IFN signaling.