An IBD-associated pathobiont synergises with NSAID to promote colitis which is blocked by NLRP3 inflammasome and Caspase-8 inhibitors
R. Singh, V. Rossini, S. R. Stockdale, G. Saiz-Gonzalo, N. Hanrahan, T. D' Souza, A. Clooney, L. A. Draper, C. Hill, K. Nally, F. Shanahan, S. Andersson-Engels, S. Melgar
The paper shows that AIEC synergizes with NSAID to worsen colitis in IL10 -/- mice, which is blocked by NLRP3 and Caspase-8 inhibitors.
bioRxiv · Aug 18, 2022Immunology