Pharmacology & ToxicologybioRxiv
In vitro testing of flash-frozen sublingual membranes for storage and reproducible permeability studies of macromolecular drugs from solution or nanofiber mats.
P. Berka, D. Stranska, V. Semecky…·P. Dolezal
The paper develops a flash-freezing method for storing porcine sublingual membranes and tests their permeability for macromolecular drugs, showing that flash-frozen membranes have lower permeability than conventionally frozen ones.
DOI 10.1016/j.ijpharm.2019.118711