Paclitaxel-loaded Cationic Fluid Lipid Nanodiscs and Liposomes with Brush-Conformation PEG Chains Penetrate Breast Tumors and Trigger Caspase-3 Activation
L. Simon-Gracia, P. D. Scodeller, W. S. Fisher, V. Sidorenko, V. M. Steffes, K. K. Ewert, C. R. Safinya, T. Teesalu
This study shows that increasing PEG coverage on cationic lipid nanoparticles improves their tumor penetration and proapoptotic activity when delivering paclitaxel.
bioRxiv · Mar 28, 2022Biophysics