V. M. Steffes

Lipids with negative spontaneous curvature decrease the solubility of the cancer drug paclitaxel in liposomes

This study shows that lipids with negative spontaneous curvature, like DOPE and GMO, reduce paclitaxel solubility in liposomes, making them unsuitable for drug delivery.

The Influence of Multivalent Charge and PEGylation on Shape Transitions in Fluid Lipid Assemblies: From Vesicles to Discs, Rods, and Spheres

This study investigates how multivalent cationic lipid MVL5 and PEG-lipids affect the structure of fluid lipid assemblies, revealing distinct morphologies like discs, rods, and spheres.

Paclitaxel-loaded Cationic Fluid Lipid Nanodiscs and Liposomes with Brush-Conformation PEG Chains Penetrate Breast Tumors and Trigger Caspase-3 Activation

This study shows that increasing PEG coverage on cationic lipid nanoparticles improves their tumor penetration and proapoptotic activity when delivering paclitaxel.

Enhanced Loading of Paclitaxel in Cationic Liposomes by Replacement of Oleoyl with Linoleoyl Lipid Tails with Benefits in Cancer Therapeutics from In Vitro Studies

This study shows that replacing oleoyl with linoleoyl lipid tails in cationic liposomes increases paclitaxel solubility, enhancing cancer therapeutic efficacy without increasing toxicity.

Distinct Solubility and Cytotoxicity Regimes of Paclitaxel-Loaded Cationic Liposomes at Low and High Drug Content Revealed by Kinetic Phase Behavior and Cancer Cell Viability Studies

This paper investigates the solubility and cytotoxicity of paclitaxel-loaded cationic liposomes at different drug contents, revealing nonmonotonic efficacy patterns linked to kinetic phase behavior.