Author

V. Srinivas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Approach:deep learning· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

E. J. R. Peterson· 2 shared H. Lebrette· 2 shared M. L. Arrieta-Ortiz· 2 shared N. S. Baliga· 2 shared A. Batyuk· 1 shared A. Bhowmick· 1 shared A. Butryn· 1 shared A. M. Orville· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

E. J. R. Peterson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Redox-controlled structural reorganization and flavin strain within the ribonucleotide reductase R2b-NrdI complex monitored by serial femtosecond crystallography

J. John, O. Aurelius, V. Srinivas, I.-S. Kim, A. Bhowmick, P. S. Simon, M. Dasgupta, C. Pham, S. Gul, K. D. Sutherlin, P. Aller, A. Butryn, A. M. Orville, M. H. Cheah, S. Owada, , M. Hogbom

The paper uses serial femtosecond crystallography to study redox-induced structural changes in the R2b-NrdI complex, revealing flavin strain and its role in superoxide generation.

bioRxiv · Apr 14, 2022Biochemistry

Transcriptome signature of cell viability predicts drug response and drug interaction for Tuberculosis

V. Srinivas, R. A. Ruiz, M. Pan, S. R. C. Immanuel, E. J. R. Peterson, N. S. Baliga

This paper develops algorithms to predict drug response and interactions in tuberculosis by analyzing transcriptome signatures of cell viability.

bioRxiv · Feb 9, 2021 · PreprintMicrobiology

PerSort facilitates characterization and elimination of persister subpopulation in mycobacteria

V. Srinivas, M. L. Arrieta-Ortiz, E. J. R. Peterson, N. S. Baliga

PerSort isolates and characterizes persister subpopulations in Mycobacterium tuberculosis, revealing their multidrug tolerance and metabolic state, and enabling their elimination under stress conditions.

bioRxiv · Apr 30, 2020Microbiology

Antibody-Recruiting Protein-Catalyzed Capture Agents to Combat Antibiotic-Resistant Bacteria

M. N. Idso, A. S. Akhade, M. L. Arrieta-Ortiz, B. T. Lai, V. Srinivas, J. P. Hopkins, A. Oliveira Gomes, N. Subramanian, N. Baliga, J. R. Heath

This paper develops AR-PCCs, a computational and synthetic approach, to rapidly create targeted antibiotics against drug-resistant bacteria by leveraging macrocyclic peptide ligands and antibody recruitment.

bioRxiv · Oct 29, 2019Bioengineering

Metal-independent ribonucleotide reduction powered by a DOPA radical in Mycoplasma pathogens

V. Srinivas, H. Lebrette, D. Lundin, Y. Kutin, M. Sahlin, M. Lerche, J. Eirich, R. Branca, N. Cox, B.-M. Sjöberg, M. Högbom

The paper identifies a metal-independent ribonucleotide reductase in Mycoplasma pathogens that uses a DOPA radical for DNA synthesis, differing from conventional RNRs.

bioRxiv · Jun 15, 2018Biochemistry