Author

M. Lerche

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:bacteria (other)· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

J. Ivaska· 2 shared P. Roca-Cusachs· 2 shared A. Brech· 1 shared A. Elosegui-Artola· 1 shared B. M. H. Bruininks· 1 shared B.-M. Sjöberg· 1 shared C. Guzman· 1 shared D. Gulberg· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

J. Ivaska

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Regulation of cell dynamics by rapid transport of integrins through the biosynthetic pathway

M. Lerche, M. Mathieu, L. Malerod, N. M. Pedersen, H. Hamidi, M. Chastney, B. M. H. Bruininks, S. Kaptan, G. Jacquemet, I. Vattulainen, P. Roca-Cusachs, A. Brech, F. Perez, G. Boncompain, S. Miserey, J. Ivaska

This study shows that integrin transport through the biosynthetic pathway rapidly alters adhesion receptor availability, enabling localized cell spreading and focal adhesion growth.

bioRxiv · Jul 12, 2022Cell Biology

Integrin binding dynamics modulate ligand-specific mechanosensing in mammary gland fibroblasts

M. Lerche, A. Elosegui-Artola, J. Z. Kechagia, C. Guzman, M. Georgiadou, D. Gulberg, P. Roca-Cusachs, E. Peuhu, J. Ivaska

This study shows that SHARPIN regulates collagen-specific mechanosensing in mammary fibroblasts by modulating integrin 11β1 activity and force transmission.

bioRxiv · Dec 20, 2019Cell Biology

Metal-independent ribonucleotide reduction powered by a DOPA radical in Mycoplasma pathogens

V. Srinivas, H. Lebrette, D. Lundin, Y. Kutin, M. Sahlin, M. Lerche, J. Eirich, R. Branca, N. Cox, B.-M. Sjöberg, M. Högbom

The paper identifies a metal-independent ribonucleotide reductase in Mycoplasma pathogens that uses a DOPA radical for DNA synthesis, differing from conventional RNRs.

bioRxiv · Jun 15, 2018Biochemistry