Development of noninvasive biomarkers of response to proteasome inhibitor therapy (ixazomib) by imaging disrupted protein homeostasis in mouse models of solid tumors
Yanan Zhu, Rajiv Ramasawmy, Sean Peter Johnson…·Simon Walker-Samuel
This study uses CEST MRI to noninvasively monitor proteasome inhibitor response in mouse tumor models, showing increased CEST signals with higher drug doses and varying tumor sensitivity.