NeuroscienceScience AdvancesPeer-reviewed
C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility
Laura Fumagalli, Florence L. Young, Steven Boeynaems…·Philip Van Damme
This study shows that C9orf72 repeat expansions produce toxic arginine-rich DPRs that disrupt axonal transport by interacting with microtubules and motor proteins, contributing to ALS/FTD.
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