Molecular BiologybioRxivPreprint
SPTF-3/SP1 orchestrates mitochondrial biogenesis upon ribosomal stress and acute starvation
Johannes CW Hemerling, Victor Pavlenko, Marija Herholz…·Aleksandra Trifunović
The paper identifies SPTF-3 as a stress-induced transcription factor regulating mitochondrial biogenesis and UPRmt in C. elegans, with its mammalian homolog SP1 showing conserved function in nutrient deprivation.
DOI 10.1101/2023.08.18.553493