Cancer BiologybioRxiv
Spatial transcriptomics analysis identifies a unique tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease
H. Alhaddad, O. E. Ospina, M. L. Khaled…·I. Smalley
This study uses spatial transcriptomics to identify a tumor-promoting role of meningeal stroma in melanoma leptomeningeal disease and shows that targeting SERPINA3 or its downstream pathway can restore drug sensitivity.
DOI 10.1016/j.xcrm.2024.101606