Author

W. Knight

Wellcome Sanger Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

A. Noorani· 1 shared A. Tovmasyan· 1 shared Aida Ferreiro-IglesiasiD· 1 shared Akihiko FukagawaiD· 1 shared Algirdas ŽalimasiD· 1 shared Andrew R. J. LawsoniD· 1 shared Anna HorňákováiD· 1 shared Anush Mukeria· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Noorani

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Systemic mutagen exposures reported by normal kidney cell genomes

Yichen Wang, W. Knight, Aida Ferreiro-Iglesias, Behnoush Abedi‐Ardekani, My H. Pham, Sarah Moody, Yvette E. Hooks, Federico Abascal, Charles Nunn, Stephen F. Fitzgerald, Thomas Cattiaux, Valérie Gaborieau, Akihiko Fukagawa, Viorel Jinga, Ștefan Rașcu, , Michael R. Stratton

The paper identifies mutational signatures in normal kidney cells from multiple countries, revealing exposure to exogenous mutagens including aristolochic acids and unknown agents prevalent in Japan.

bioRxiv · Apr 9, 2026 · PreprintGenomics

Pre-cancerous Niche Remodelling Dictates Nascent Tumour Survival

Greta Skrupskelyte, Jesús Eduardo Rojo Arias, Harikrishnan Ajith, Y. Dang, D. Rossetti, S. Han, M. K. S. Tang, Maria Teresa Béjar, Bartomeu Colom, J. C. Fowler, K. Murai, W. Knight, Daniela Ellen Aust, M. H. H. Schmidt, József Jászai, , Maria Pilar Alcolea

The paper shows that pre-cancerous niche remodeling by early tumour cells determines nascent tumour survival in mice.

Nature · Mar 4, 2026Peer-reviewedCancer Biology

Quisinostat is a brain-penetrant radiosensitizer in glioblastoma

C. Lo Cascio, T. Margaryan, E. L. Melendez, J. B. McNamara, C. I. White, W. Knight, S. Ganta, Z. Opachich, W. Yoo, N. Sanai, S. Mehta, A. Tovmasyan

This study shows that quisinostat, a selective HDAC1/2 inhibitor, is brain-penetrant and enhances radiation therapy efficacy in glioblastoma models.

JCI Insight · Nov 22, 2023Peer-reviewedCancer Biology