Author

K. Murai

Wellcome Sanger Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cancer & tumor microenvironment· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. Herms· 4 shared D. Fernandez-Antoran· 4 shared P. H. Jones· 4 shared B. Colom· 3 shared G. Piedrafita· 3 shared S. H. Ong· 3 shared B. A. Hall· 2 shared M. Gerstung· 2 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCell Biology

A. Herms

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Pre-cancerous Niche Remodelling Dictates Nascent Tumour Survival

Greta Skrupskelyte, Jesús Eduardo Rojo Arias, Harikrishnan Ajith, Y. Dang, D. Rossetti, S. Han, M. K. S. Tang, Maria Teresa Béjar, Bartomeu Colom, J. C. Fowler, K. Murai, W. Knight, Daniela Ellen Aust, M. H. H. Schmidt, József Jászai, , Maria Pilar Alcolea

The paper shows that pre-cancerous niche remodeling by early tumour cells determines nascent tumour survival in mice.

Nature · Mar 4, 2026Peer-reviewedCancer Biology

Epithelioids: Self-sustaining 3D epithelial cultures to study long-term processes

A. Herms, D. Fernandez-Antoran, M. Alcolea, A. Kalogeropoulou, U. Banerjee, G. Piedrafita, E. Abby, J. A. Valverde-Lopez, I. S. Ferreira, S. Dentro, S. H. Ong, B. Colom, K. Murai, C. King, K. T. Mahbubani, , P. H. Jones

This paper introduces epithelioids, a 3D culture system for mouse and human epithelia that maintains structure and function over long periods, enabling study of long-term biological processes.

bioRxiv · Jan 3, 2023Cell Biology

p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition

K. Murai, S. Dentro, S. H. Ong, R. Sood, D. Fernandez-Antoran, A. Herms, V. Kostiou, B. A. Hall, M. Gerstung, P. H. Jones

This study shows p53 mutations in normal esophagus drive clonal expansion but are constrained by clonal competition, and LOH is critical for malignant transformation.

bioRxiv · Feb 3, 2022Cancer Biology

Levelling out differences in aerobic glycolysis neutralizes the competitive advantage of oncogenic PIK3CA mutant progenitors in the esophagus

A. Herms, B. Colom, G. Piedrafita, K. Murai, S. H. Ong, D. Fernandez-Antoran, C. Bryant, C. Frezza, B. Vanhaesebroeck, P. H. Jones

The paper shows that reducing aerobic glycolysis differences between mutant and wild-type cells limits the competitive advantage of PIK3CA mutant progenitors in the esophagus.

bioRxiv · May 28, 2021Cancer Biology

The single-progenitor model as the unifying paradigm of squamous epithelial maintenance

G. Piedrafita, V. Kostiou, A. Wabik, B. Colom, D. Fernandez-Antoran, A. Herms, K. Murai, B. A. Hall, P. H. Jones

This study uses lineage tracing and proliferation assays to show that squamous epithelial tissues are maintained by a single population of proliferating cells, not multiple stem cell types.

bioRxiv · Jul 26, 2019Cell Biology