W. N. Cooper

This paper introduces INVAR, a method to improve ctDNA detection sensitivity using patient-specific sequencing panels and variant read integration, achieving ppm-level detection in clinical samples.

The paper uses sequencing methods to show that cell-free tumour DNA levels are low in renal cancer but can still be informative with improved detection strategies.

This paper develops a protocol to detect ctDNA from dried blood spots using low-depth WGS and fragment size selection, showing its feasibility in human and mouse models.