Author

D. Gale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Research Focus:variant calling· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

C. G. Smith· 3 shared I. Hudecova· 3 shared J. C. Wan· 3 shared K. Heider· 3 shared N. Rosenfeld· 3 shared W. N. Cooper· 3 shared D. Chandrananda· 2 shared F. Mouliere· 2 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

C. G. Smith

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Kidney organoids: A system to study human basement membrane assembly in health and disease

M. R. Morais, P. Tian, C. Lawless, S. Murtuza-Baker, L. Hopkinson, S. Woods, A. Mironov, D. A. Long, D. Gale, T. M. Zorn, R. Zent, R. Lennon

This study uses kidney organoids to investigate basement membrane assembly dynamics, identifying conserved temporal patterns and pathogenic variant effects.

bioRxiv · Jun 27, 2021Cell Biology

High-sensitivity monitoring of ctDNA by patient-specific sequencing panels and integration of variant reads

J. C. Wan, K. Heider, D. Gale, S. Murphy, E. Fisher, J. Morris, F. Mouliere, D. Chandrananda, A. Marshall, A. B. Gill, P. Y. Chan, E. Barker, G. Young, W. N. Cooper, I. Hudecova, , N. Rosenfeld

This paper introduces INVAR, a method to improve ctDNA detection sensitivity using patient-specific sequencing panels and variant read integration, achieving ppm-level detection in clinical samples.

bioRxiv · Sep 11, 2019 · PreprintCancer Biology

Comprehensive characterisation of cell-free tumour DNA in plasma and urine of patients with renal tumours

C. G. Smith, T. Moser, J. Burge, M. Eldridge, A. L. Riediger, F. Mouliere, D. Chandrananda, K. Heider, J. C. Wan, A. Y. Warren, J. Morris, I. Hudecova, W. N. Cooper, T. J. Mitchell, D. Gale, , G. D. Stewart

The paper uses sequencing methods to show that cell-free tumour DNA levels are low in renal cancer but can still be informative with improved detection strategies.

bioRxiv · Sep 11, 2019 · PreprintCancer Biology

Detection of ctDNA from dried blood spots after DNA size selection

K. Heider, J. C. Wan, J. Hall, S. Boyle, I. Hudecova, D. Gale, W. N. Cooper, P. G. Corrie, J. D. Brenton, C. G. Smith, N. Rosenfeld

This paper develops a protocol to detect ctDNA from dried blood spots using low-depth WGS and fragment size selection, showing its feasibility in human and mouse models.

bioRxiv · Sep 5, 2019Cancer Biology