Mitochondrial structure and function adaptation in residual triple negative breast cancer cells surviving chemotherapy treatment
M. L. Baek, J. Lee, K. E. Pendleton, M. J. Berner, E. B. Goff, L. Tan, S. A. Martinez, T. Wang, M. D. Meyer, B. Lim, J. P. Barrish, W. Porter, P. L. Lorenzi, G. V. Echeverria
This study identifies how residual triple negative breast cancer cells adapt mitochondrial structure and function to survive chemotherapy, showing that DNA-damaging agents promote mitochondrial fusion and OXPHOS, which can be targeted with OPA1 inhibitors.
bioRxiv · Feb 25, 2022Cancer Biology