C. Young

BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance

This study identifies secondary splice-site mutations in BRCA1 that drive exon skipping and PARP inhibitor resistance in ovarian and breast cancer.

A Collaborative DNA Barcode Library for the Diptera of Churchill, Canada: Exploration of Biodiversity and Biogeography

The paper presents a DNA barcode library for Diptera in Churchill, Canada, revealing biodiversity patterns and molecular evolution insights.

Involvement of ArlI, ArlJ, and CirA in Archaeal Type-IV Pilin-Mediated Motility Regulation

This study identifies ArlI, ArlJ, and CirA as regulators of pilin-mediated motility in Haloferax volcanii through genetic and expression analyses.

Self-reactive B cells traverse a perfect storm of somatic mutagenesis to cause a virus-induced autoimmune disease

The paper traces the evolution of autoantibodies in HCV-CV patients, revealing convergent somatic mutations and compromised solubility in pathogenic B cells.

Analysis of an Indian colorectal cancer faecal microbiome collection demonstrates universal colorectal cancer-associated patterns, but closest correlation with other Indian cohorts.

The paper analyzes an Indian colorectal cancer fecal microbiome cohort, showing global CRC-associated patterns but highlighting regional variations and the importance of local studies.

Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1 (DMT1): Preclinical Efficacy Against Iron Overload and Safety Evaluation

This paper identifies XEN602, a potent, gut-restricted DMT1 inhibitor, showing efficacy in reducing iron overload in rats and pigs with minimal systemic exposure.

Magnetic Enrichment of Immuno-Specific Extracellular Vesicles for Mass Spectrometry Using Biofilm-Derived Iron Oxide Nanowires

This paper develops a method to enrich immuno-specific extracellular vesicles using magnetic iron oxide nanowires for mass spectrometry, showing comparable performance to commercial beads.

NBI-921352, a First-in-Class, Na V 1.6 Selective, Sodium Channel Inhibitor That Prevents Seizures in Scn8a Gain-of- Function Mice, and Wild-Type Mice and Rats

This paper describes NBI-921352, a selective NaV1.6 inhibitor that prevents seizures in Scn8a gain-of-function mice and wild-type models, with better efficacy and tolerability than existing antiseizure drugs.

Probing Specificities of Alcohol Acyltransferases for Designer Ester Biosynthesis with a High-Throughput Microbial Screening Platform

This paper develops a high-throughput microbial screening platform to identify AATs for selective designer ester biosynthesis, demonstrating its effectiveness with specific AAT variants.

Sick and Tired: Polyparasitism, Food Stress and Sickness Behaviour in a Gregarious Mammal

This study examines how food stress and co-infection with parasites affect sickness behaviour in wild vervet monkeys, finding that food availability is the main driver of behavioural changes.

Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in mice

Reduced PAX5 function in mice leads to uncommitted B cell development and B-ALL with secondary mutations in Jak3 and Ptpn11.

Infrared thermography cannot be used to approximate core body temperature in wild primates

This study shows that infrared thermography cannot reliably approximate core body temperature in wild vervet monkeys when local climate effects are controlled.

Effects of scent enrichment on behavioural andphysiological indicators of stress in zoo primates

This study evaluates the impact of essential oil scent enrichment on stress indicators in zoo primates, finding mixed effects across species.

Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races

The paper uses deep mutational scanning to assess how mutations in the TRIM5 v1 loop affect retroviral restriction, finding that most mutations enhance or preserve antiviral function.

Detecting Direct Oral Anticoagulants in Trauma Patients using Liquid Chromatography-Mass Spectrometry: a Novel Approach to Medication Reconciliation

This paper develops an LCMS-based assay to detect DOACs in trauma patients, achieving high accuracy and identifying potential medication reconciliation issues.

Cross-talk between SIM2s and NFkB regulates cyclooxygenase 2 expression in breast cancer

This study shows that SIM2s inhibits NFkB activation and COX-2 expression in breast cancer, suggesting a potential therapeutic target.