Live-cell Imaging Analysis of Antimycin-Type Depsipeptides via Bioorthogonal Stimulated Raman Scattering Microscopy
J. A. Seidel, Y. Miao, W. Porterfield, W. Cai, X. Zhu, S.-J. Kim, F. Hu, S. Bhattarai-Kline, W. Min, W. Zhang
This study uses bioorthogonal SRS microscopy to analyze the intracellular distribution of antimycin-type depsipeptides in living cells, showing their enrichment depends on potency, protein targets, and lipophilicity.
bioRxiv · Mar 21, 2019 · PreprintBioengineering