F. Hu

Dimer-monomer transition defines a hyper-thermostable peptidoglycan hydrolase mined from bacterial proteome by lysin-derived antimicrobial peptide-primed screening

The paper identifies hyper-thermostable peptidoglycan hydrolases from bacterial proteomes using lysin-derived antimicrobial peptide screening and shows their potent bactericidal activity.

IL-3-driven T cell-basophil crosstalk enhances anti-tumor immunity

This study shows that IL-3 enhances anti-tumor immunity by promoting CTL-basophil interactions, improving CTL activity and tumor suppression.

Macrophage migrates on alternate non-adhesive surfaces

This study shows macrophages can migrate across non-adhesive PEG surfaces by adopting a mesenchymal mode, overcoming the limitations seen in other cell types.

Glycopeptide antibiotic teicoplanin inhibits cell entry of SARS-CoV-2 by suppressing the proteolytic activity of cathepsin L

This paper shows that teicoplanin inhibits SARS-CoV-2 cell entry by blocking cathepsin L proteolytic activity, effective against multiple variants with IC50 values of 2.038 M and 2.116 M.

Extensive neutralization against SARS-CoV-2 variants elicited by Omicron-specific subunit vaccine booster

This study shows that an Omicron-specific subunit vaccine booster enhances neutralizing antibodies against SARS-CoV-2 variants and the ancestral virus, with a two-dose WT-RBD plus Omicron-RBD booster showing the strongest response.

3D Printable High Performance Conducting Polymer Hydrogel for All-Hydrogel Bioelectronics

This paper develops a bi-continuous conducting polymer hydrogel with high electrical conductivity, stretchability, and fracture toughness for 3D printable bioelectronics.

CFAP61 is required for sperm flagellum formation and male fertility in human and mouse

This study identifies CFAP61 as essential for sperm flagellum formation and male fertility in humans and mice, showing its role in axoneme stabilization and its mutation causing infertility.

Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells

This study develops an organoid-based method to generate large quantities of NK cells from human pluripotent stem cells without feeder cells, achieving efficient and scalable iNK cell production.

Natural killer-like B cells promote Th17 cell differentiation and exacerbate rheumatoid arthritis

This study identifies natural killer-like B cells as pathogenic in rheumatoid arthritis by promoting Th17 differentiation and disease severity.

Hoxb5 reprograms murine multipotent blood progenitors into hematopoietic stem cell-like cells

This study shows that Hoxb5 can convert multipotent blood progenitors into hematopoietic stem cell-like cells with long-term repopulating ability.

Regeneration of humoral immunity from pluripotent stem cells by defined transcription factors

This study regenerates functional B lymphopoiesis from pluripotent stem cells (PSCs) using Runx1, Hoxa9, and Lhx2, producing antigen-specific antibodies and immune memory in B-cell deficient animals.

Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism

The paper determines high-resolution structures of outer-arm dynein arrays bound to microtubule doublets, revealing a mechanism for motor coordination through ATP hydrolysis and tail-to-head interactions.

Blocking of EGFR Signaling is a Latent Strategy for the Improvement of Prognosis of HPV Induced Cancer

This study identifies EGFR downregulation as a mechanism by which HPV infection improves prognosis in cervical and head and neck cancers, suggesting EGFR inhibitors could be potential anti-HPV therapies.

Ferroportin 3 is a dual-targeted mitochondrial/chloroplast iron exporter necessary for iron homeostasis in Arabidopsis

This study identifies FPN3 as a dual-targeted iron exporter in Arabidopsis mitochondria and chloroplasts, essential for iron homeostasis and growth under iron deficiency.

An ABA Synthesis Enzyme Allele OsNCED2 Promotes the Aerobic Adaption in Upland Rice

This study identifies an OsNCED2 allele that enhances aerobic adaptation in upland rice by improving root development and drought tolerance through increased ABA synthesis.

The therapeutic effects of intratumoral injection of IL12IL2GMCSF fusion protein on canine tumors

This study evaluates the therapeutic effects of IL12IL2GMCSF fusion protein in canine tumors, showing significant response rates with minimal adverse effects.

Transposable elements contribute to regulatory hub stress-related long noncoding RNAs in Maize

The paper identifies and characterizes lncRNAs in maize, finding that many are derived from transposable elements and play regulatory roles in abiotic stress responses.

Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors

This study demonstrates that transient expression of Runx1 and Hoxa9 in pluripotent stem cells generates functional T cells capable of immune surveillance and tumor eradication.

Mining the human tonsillar microbiota as autoimmune modulator

The paper identifies dysbiosis in RA tonsillar microbiota and shows that Streptococcus salivarius and its antibacterial peptides modulate autoimmunity by suppressing T cells and autoantibodies.

Single cell RNA-seq reveals cellular diversity and developmental characteristics of human infant retina

This study uses single-cell RNA-seq to analyze human infant retina, identifying cell types, communication networks, and developmental changes, providing a resource for retinal research and regenerative medicine.

Single cell RNA sequencing reveals cellular diversity of trisomy 21 retina

This study uses single-cell RNA sequencing to analyze the cellular diversity and molecular markers in the retina of a trisomy 21 fetus, revealing communication networks and novel markers.

Hypotonic stress induces fast, reversible degradation of the vimentin cytoskeleton via intracellular calcium release

The paper shows hypotonic stress causes rapid, reversible vimentin cytoskeleton degradation via calcium release and calpain proteolysis, preceding changes in other cytoskeletal systems.

Study on the Health Communication Behavior of Chinese Doctors on Network Media----Based on the Empirical Investigation of 119 Chinese Doctors

This paper investigates the health communication behavior of Chinese doctors on online media, finding that their involvement is low and influenced by media use and self-efficacy.

Live-cell Imaging Analysis of Antimycin-Type Depsipeptides via Bioorthogonal Stimulated Raman Scattering Microscopy

This study uses bioorthogonal SRS microscopy to analyze the intracellular distribution of antimycin-type depsipeptides in living cells, showing their enrichment depends on potency, protein targets, and lipophilicity.

SMCR8 negatively regulates AKT and MTORC1 signaling to modulate lysosome biogenesis and tissue homeostasis

This study shows that SMCR8 regulates MTORC1 and AKT signaling, affecting lysosome biogenesis and tissue homeostasis, with loss of SMCR8 causing splenomegaly and autoimmune-like phenotypes.