Evolutionary BiologybioRxiv
Mutations that improve the efficiency of a weak-link enzyme are rare compared to adaptive mutations elsewhere in the genome
A. B. Morgenthaler, W. R. Kinney, C. C. Ebmeier…·S. D. Copley
The paper shows that mutations improving a weak-link enzyme's efficiency are rare compared to other adaptive mutations in the genome during bacterial evolution.
DOI 10.7554/elife.53535