Cancer BiologybioRxiv
Loss of ACKR4 in tumor cells dysregulates dendritic cell migration to tumor-draining lymph nodes and T-cell priming
D. Wangmo, P. K. Premsrirut, C. Yuan…·S. Subramanian
This study shows that loss of ACKR4 in colorectal cancer cells impairs dendritic cell migration and T-cell priming, leading to immune checkpoint blockade resistance.
DOI 10.3390/cancers13195021