Structure-guided synthesis of FK506 and FK520 analogs with increased selectivity exhibit in vivo therapeutic efficacy against Cryptococcus
M. J. Hoy, E. Park, H. Lee, W. Y. Lim, D. C. Cole, N. D. DeBouver, B. G. Bobay, P. G. Pierce, D. Fox, M. Ciofani, P. R. Juvvadi, W. Steinbach, J. Hong, J. Heitman
This paper develops FK506 analogs with improved fungal selectivity and antifungal efficacy, showing reduced immunosuppression and therapeutic benefit in fungal infection models.
bioRxiv · Mar 25, 2022Microbiology