Author

D. Fox

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Ecology· 1 Immunology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:mouse· 6 Research Focus:cell type annotation· 4 Research Focus:drug response / drug discovery· 4 Organism:human· 4 Assay:proteomics· 4 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

S. Stanley· 3 shared A. Anaya-Sanchez· 2 shared A. Rustagi· 2 shared C. A. Blish· 2 shared D. I. Kotov· 2 shared J. Heitman· 2 shared S. Espich· 2 shared X. H. Nguyenla· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersMicrobiology

S. Stanley

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Non-invasive hormone assessment of Australian Merino Rams (Ovis aries): A pilot investigation of cortisol, testosterone and heat stress

D. Fox, B. Wilson, E. Narayan

This study assesses cortisol and testosterone in wool samples of Australian Merino Rams to evaluate non-invasive hormone assessment and its correlation with heat stress.

bioRxiv · Jun 12, 2024 · PreprintPhysiology

Impaired aldehyde detoxification caused by a common human polymorphism promotes anti-bacterial immunity

S. Espich, S. Berry, X. Chang, A. Balakhmet, N. T. T. Thuong, R. Dorajoo, C. C. Khor, C. K. Heng, J.-M. Yuan, W.-P. Koh, D. Fox, A. Anaya-Sanchez, L. Tenney, C. J. Chang, R. Baral, , S. A. Stanley

The paper shows ALDH2 deficiency enhances anti-bacterial immunity by increasing aldehyde levels that kill pathogens and boost inflammatory responses.

bioRxiv · Aug 24, 2023 · PreprintMicrobiology

Tuberculosis susceptibility in genetically diverse mice reveals functional diversity of neutrophils

M. M. Ravesloot-Chavez, E. Van Dis, D. Fox, A. Anaya-Sanchez, S. Espich, X. H. Nguyenla, S. L. Rawal, H. Samani, M. A. Ballinger, H. Thomas, D. I. Kotov, R. Vance, M. Nachman, S. Stanley

The paper identifies a novel neutrophil signature associated with poor tuberculosis control in genetically diverse mice.

bioRxiv · Jun 29, 2023Immunology

Structure-guided synthesis of FK506 and FK520 analogs with increased selectivity exhibit in vivo therapeutic efficacy against Cryptococcus

M. J. Hoy, E. Park, H. Lee, W. Y. Lim, D. C. Cole, N. D. DeBouver, B. G. Bobay, P. G. Pierce, D. Fox, M. Ciofani, P. R. Juvvadi, W. Steinbach, J. Hong, J. Heitman

This paper develops FK506 analogs with improved fungal selectivity and antifungal efficacy, showing reduced immunosuppression and therapeutic benefit in fungal infection models.

bioRxiv · Mar 25, 2022Microbiology

Genetic interaction analysis reveals that Cryptococcus neoformans utilizes multiple acetyl-CoA-generating pathways during infection

K. M. Alden, A. J. Jezewski, S. R. Beattie, D. Fox, D. J. Krysan

This study identifies multiple acetyl-CoA-generating pathways in Cryptococcus neoformans essential for infection, showing synthetic lethality between ACL1 and ACS1 and reduced fitness in vivo.

bioRxiv · Mar 16, 2022Microbiology

AUG-3387, a Human-Derived Monoclonal Antibody Neutralizes SARS-CoV-2 Variants and Reduces Viral Load from Therapeutic Treatment of Hamsters In Vivo

C. J. Emig, M. A. Mena, S. J. Henry, A. Vitug, C. J. Ventura, D. Fox, X. H. Nguyenla, H. Xu, C. Moon, S. Sahakijjpijarn, P. J. Kuehl, D. Revelli, Z. Cui, R. O. Williams, D. J. Christensen

AUG-3387, a human monoclonal antibody, neutralizes SARS-CoV-2 variants and reduces viral load in hamsters when administered as a dry powder inhaler formulation.

bioRxiv · Oct 12, 2021 · PreprintPharmacology & Toxicology

The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamsters

T. Carroll, D. Fox, N. van Doremalen, E. Ball, M. K. Morris, A. Sotomayor-Gonzalez, V. Servellita, A. Rustagi, C. K. Yinda, L. Fritts, J. R. Port, Z.-M. Ma, M. Holbrook, J. Schulz, C. A. Blish, , C. J. Miller

This study shows that the B.1.427/1.429 (epsilon) SARS-CoV-2 variants cause more severe disease and higher viral loads in the upper respiratory tract in Syrian hamsters compared to the ancestral B.1 (614G) strain.

bioRxiv · Aug 25, 2021Microbiology

An intranasal ASO therapeutic targeting SARS-CoV-2

C. Zhu, J. Y. Lee, J. Z. Woo, L. Xu, X. Nguyenla, L. H. Yamashiro, F. Ji, S. B. Biering, E. V. Dis, F. Gonzalez, D. Fox, A. Rustagi, B. A. Pinsky, C. A. Blish, C. Chiu, , A. M. Näär

This paper develops an intranasal ASO therapy targeting SARS-CoV-2 RNA that effectively prevents viral replication in multiple models and variants.

bioRxiv · May 17, 2021Microbiology

Horizontal gene transfer in the human and skin commensal Malassezia: a bacterially-derived flavohemoglobin is required for NO resistance and host interaction

G. Ianiri, M. A. Coelho, F. Ruchti, F. Sparber, T. J. McMahon, C. Fu, M. Bolejack, O. Donovan, H. Smutney, P. Myler, F. Dietrich, D. Fox, S. LeibundGut-Landmann, J. Heitman

This study identifies bacterially-derived flavohemoglobin in Malassezia, acquired via horizontal gene transfer, as essential for nitric oxide resistance and host interaction.

Proceedings of the National Academy of Sciences · Jun 23, 2020Peer-reviewedMicrobiology

Functional diversification enabled grassy biomes to fill global climate space

C. Lehmann, D. Griffith, K. Simpson, M. Anderson, S. Archibald, D. Beerling, W. Bond, E. Denton, E. Edwards, E. Forrestel, D. Fox, D. Georges, W. Hoffmann, T. Kluyver, L. Mucina, , C. Osborne

The paper maps global grassy biomes and identifies key traits and lineages driving their distribution across climates.

bioRxiv · Mar 21, 2019 · PreprintEcology