Wangsheng Li

Integrated optimization of experimental and computational workflows improves genome recovery in long-read gut metagenomics

Single-Cell Multi-Omics Dissects Transcript Isoform and Immune Repertoire Dynamics in Human Immunosenescence

This study uses single-cell multi-omics to analyze transcript isoform and immune repertoire changes in aging human immune cells, identifying age-related molecular features in T cells and B cells.

Complete genome-derived metabolic interactions reveal impact of gut ecology on human health

This study uses complete genomes to model gut microbiome metabolic interactions, revealing ecological group dynamics linked to inflammatory bowel disease and improving disease diagnosis.

Decoding Immune Reconstitution Failure in People Living with HIV through Single-cell Genomics

This study uses single-cell multi-omics to analyze immune reconstitution failure in HIV patients, identifying genetic and epigenetic factors and developing a predictive model.

Complete Genomes of Cultivated Gut Bacteria Reveal Mobile Genetic Element-Driven Functional Diversity with Therapeutic Implications

The paper presents a comprehensive compendium of fully circularized human gut bacterial genomes and reveals how mobile genetic elements drive functional diversity with therapeutic implications.

Spatial transcriptomics elucidates the central role of cerebral vasculatures in the progression of Japanese encephalitis

This study uses spatial transcriptomics to show that cerebral vasculatures, particularly meninges, drive inflammation and tissue damage in Japanese encephalitis by forming a feedback loop involving immune cells and cell death mechanisms.

Telomere-to-telomere African wild rice (Oryza longistaminata) reference genome reveals segmental and structural variation

The paper presents a telomere-to-telomere genome assembly for Oryza longistaminata, revealing structural variations and gene duplications that may contribute to its advantageous traits.

Large-scale population genomics of Malayan pangolins reveals deep diversification and a new species

This study reveals deep genetic differentiation in Malayan pangolins, identifies two new genetic populations, and proposes a new species closely related to the Philippine pangolin.

High-resolution spatiotemporal transcriptomic maps of developing Drosophila embryos and larvae

This study uses Stereo-seq to generate high-resolution spatiotemporal transcriptomic maps of Drosophila embryos and larvae, revealing new subregions and gene regulatory networks.

Genetic characteristics of human papillomavirus type 16, 18, 52 and 58 in southern China

The paper analyzes the genetic diversity of HPV types 16, 18, 52, and 58 in southern China, identifying sublineages and mutations associated with oncogenic potential.