Molecular BiologybioRxivPreprint
CRISPR/Cas9-mediated identification of human macrophage SphK1 as druggable target for development of anti-leishmanial chemotherapeutics
Evanka Madan, Jhalak Singhal, Aashima Gupta…·Shailja Singh
This study identifies SphK1 as a druggable target in human macrophages for anti-leishmanial therapy by showing its role in promoting Leishmania donovani survival through immune evasion and cell fate regulation.
DOI 10.1101/2025.08.18.670766